Genetic studies in nzb mice
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چکیده
منابع مشابه
1188 Genetic Studies in Nzb Mice
The genetic basis for autoimmunity in New Zealand mice has been investigated for two decades. These studies have suggested that several genes underlie the autoimmune process (1-10). The advent of new murine models of autoimmunity that display some of the traits of NZB mice while lacking others has led to a resurgence of interest in the genetic basis for autoimmunity (11-14). The major question ...
متن کاملGenetic studies in NZB mice. I. Spontaneous autoantibody production
The appearance of naturally occurring thymocytotoxic autoantibodies (NTA) and spontaneously produced antibodies to single-stranded DNA (ssDNA) was studied in NZB, and DBA/2 mice and their F1 and backcross progeny. NTA production was markedly decreased in males; however, castrated males produced quantities of NTA similar to those of females. Because the amount of NTA was influenced by sex hormon...
متن کامل1188 Genetic Studies in Nzb
The genetic basis for autoimmunity in New Zealand mice has been investigated for two decades. These studies have suggested that several genes underlie the autoimmune process (1-10). The advent of new murine models of autoimmunity that display some of the traits of NZB mice while lacking others has led to a resurgence of interest in the genetic basis for autoimmunity (11-14). The major question ...
متن کاملGenetic studies in NZB mice. V. Recombinant inbred lines demonstrate that separate genes control autoimmune phenotype
The genetic basis for autoimmunity in NZB mice has been investigated through analysis of recombinant inbred lines produced by mating NZB mice with two different non-autoimmune strains. Several genes (at least six) were found to be necessary for the production of eight traits characteristic of the NZB mice that were studied. No fundamental genetic defect (an "autoimmunity gene") was identified t...
متن کاملImmunologic Studies of Autoimmune Disease in Nzb/nzw F1 Mice
For the past 3 years NZB and NZW mice have been maintained by sister-brother matings from English breeder stock. NZB/NZW F(1) hybrids developed lupus-like nephritis during the 6th to 7th month and few survived beyond the 8th month. Renal tissues of these animals were examined with fluorescein-labeled antinucleoside sera, specific for thymine and cytosine, for the presence of denatured DNA in GC...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1980
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780230109